Dr. Deepak Kotiya, Ph.D.

Scientist I

Dr. Kotiya is working as a scientist in the Department of Pharmacology and Nutritional Sciences at the University of Kentucky. He received his Ph.D. in Molecular Medicine from the Jawaharlal Nehru University (New Delhi, India, 2016) for his work on the role of endocrine receptor PXR on hepatocellular carcinoma. Later he joined the University of Kentucky for his postdoctoral work on the effect of endocrine hormone amylin dyshomeostasis on Alzheimer’s disease. His current work focuses on delineating the mechanisms underlying the association between pancreatic amyloid-forming amylin and cerebral Aβ pathology in Alzheimer’s disease. In this regard, he uses his molecular and cell biology expertise in the generation of antibodies, the development of new assays (ELISA), and working with various rodent models transgenic to human amylin and beta-amyloid. In his current projects, he is working on 1) conditional mice models transgenic for human amylin in the pancreas with the presence/absence of APP/PS1 gene where human amylin gene expression can be either upregulated or downregulated by Tamoxifen treatment. 2) passive amylin immunotherapy to reduce the amylin and beta-amyloid plaque burden in AD mice model.